NASA astronaut Anil Menon and CSA astronaut Joshua Kutryk will install and deploy the eighth and final IROSA on the 3B channel of the space station, completing the power augmentation upgrades.

BepiColombo will perform a burn to insert itself into an orbit around Mercury. Shortly after arriving at the planet, BepiColombo will begin studying the composition, geophysics, atmosphere, magnetosphere, and history of Mercury. Shortly before the burn will begin the transfer module will separate.

Cargo Dragon C211 will undock autonomously from the Harmony module on the International Space Station after a one-month stay, orbit the Earth, and then splashdown in the Pacific Ocean.