Cargo Dragon CRS-35 will autonomously dock to the Harmony module of the International Space Station (ISS).

BepiColombo will perform a burn to insert itself into an orbit around Mercury. Shortly after arriving at the planet, BepiColombo will begin studying the composition, geophysics, atmosphere, magnetosphere, and history of Mercury. Shortly before the burn will begin the transfer module will separate.

ESA's Hera will use its engines as brakes to slow the spacecraft down to enter an orbit around Didymos.