The Space Launch System (SLS) rocket for the Artemis II mission will perform a Wet Dress Rehearsal to demonstrate the ability to load more than 700,000 gallons of cryogenic propellants into the rocket, conduct a launch countdown, and practice safely removing propellant from the rocket without astronauts inside the spacecraft.

Cargo Dragon CRS-33 will undock autonomously from the Harmony module on the International Space Station after a six-month stay, orbit the Earth, and then splashdown in the Pacific Ocean.

Northrop Grumman's NG-23 Cygnus-XL spacecraft will be released from the International Space Station ahead of a destructive reentry into Earth's atmosphere.