The Orion Integrity will splash down in the ocean with the Artemis II mission composed of NASA astronauts commander Reid Wiseman, pilot Victor Glover and mission specialist Christina Koch, and mission specialist Jeremy Hansen of Canada's CSA, after a 10-day mission around the Moon.

The Cygnus (NG-24) cargo resupply spacecraft will be captured by the robotic Canadarm2 on the International Space Station.

JAXA's Hayabusa2 spacecraft will fly by the near-Earth asteroid Torifune (2001 CC21). Hayabusa2 will approach within 100 km (62 mi) of Torifune at a relative speed of 5 km/s (3.1 mi/s).